The long-term objective of the TeamEndo research program is to understand how the brain and pituitary transduce environmental and physiological signals into changes in reproductive function. A deep understanding of neuroendocrinology is fundamental to our understanding of successful vertebrate reproduction under normal conditions or when the environment is under stress from pollution. More recent research is beginning to examine the hormones and neurotransmitters that regulate stem-like neurosteroidogenic radial glia. The team studies the effects of sex steroids and pollutants (pharmaceuticals, pesticides, petroleum products) on neuroendocrine processes in fish and frogs using both in vivo and in vitro approaches. Other research examines the effects of such pollutants on sexual development and metamorphosis in frogs. The work has shown that the brain is a major target for the actions of contaminants and that these disrupt normal development and reproduction. Such research has helped to shape the emerging field of “neuroendocrine disruption.”

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